Transcrit NP_001001890

Seqüència de la proteïna:

MRIPVDASTSRRFTPPSTALSPGKMSEALPLGAPDAGAALAGKLRSGDRSMVEVLADHPGELVRTDSPNFLCSVLPTHWRCNKTLPIAFKVVALGDVP
DGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPRRHRQKLDDQTKPGSLSFSE
RLSELEQLRRTAMRVSPHHPAPTPNPRASLNHSTAFNPQPQSQMQDTRQIQPSPPWSYDQSYQYLGSIASPSVHPATPISPGRASGMTTLSAELSSRL
STAPDLTAFSDPRQFPALPSISDPRMHYPGAFTYSPTPVTSGIGIGMSAMGSATRYHTYLPPPYPGSSQAQGGPFQASSPSYHLYYGASAGSYQFSMV
GGERSPPRILPPCTNASTGSALLNPSLPNQSDVVEAEGSHSNSPTNMAPSARLEEAVWRPY

Esquema dels exons:

A diferència del transcrit principal aquest només presenta 6 exons. Concretament el primer exó es correspondria a l'exó 3 del transcrit principal. El codó que codifica pel primer aminoàcid d'aquest exó està format per l'últim nucleòtid de l'exó 2 i els dos primers nucleòtids de l'exó tres. Per això, aquest nou transcrit comença la traducció a una metionina que hi ha 16 residus upstream. La resta d'exons són iguals al transcrit principal i presenta dues regions UTRs al principi de l'exó 1 i al final de l'exó 6.

Localització al cromosoma 21:   35,182,857 - 35,081,975

Seqüència nucleotídica:

acgt seqüència intrònica acgt seqüència 5' upstream i 3' downstream
ACGT seqüència exònica codificant ACGT seqüència exònica no codificant (UTRs)

Regió N° nucleotids Seqüència
5' upstream
aatggaattcctccggccgggcttacagtaaaagcacgttcatttccaggcactctcatt
Exó 1 1.848
CATAGAGCCAGCGGGCGCGGGCGGGACGGGCGCCCCGCGGCCGGACCCAGCCAGGGCACC
ACGCTGCCCGGCCCTGCGCCGCCAGGCACTTCTTTCCGGGGCTCCTAGGGACGCCAGAAG
GAAGTCAACCTCTGCTGCTTCTCCTTGGCCTGCGTTGGACCTTCCTTTTTTTGTTGTTTT
TTTTTGTTTTTCCCCTTTCTTCCTTTTGAATTAACTGGCTTCTTGGCTGGATGTTTTCAA
CTTCTTTCCTGGCTGCGAACTTTTCCCCAATTGTTTTCCTTTTACAACAGGGGGAGAAAG
TGCTCTGTGGTCCGAGGCGAGCCGTGAAGTTGCGTGTGCGTGGCAGTGTGCGTGGCAGGA
TGTGCGTGCGTGTGTAACCCGAGCCGCCCGATCTGTTTCGATCTGCGCCGCGGAGCCCTC
CCTCAAGGCCCGCTCCACCTGCTGCGGTTACGCGGCGCTCGTGGGTGTTCGTGCCTCGGA
GCAGCTAACCGGCGGGTGCTGGGCGACGGTGGAGGAGTATCGTCTCGCTGCTGCCCGAGT
CAGGGCTGAGTCACCCAGCTGATGTAGACAGTGGCTGCCTTCCGAAGAGTGCGTGTTTGC
ATGTGTGTGACTCTGCGGCTGCTCAACTCCCAACAAACCAGAGGACCAGCCACAAACTTA
ACCAACATCCCCAAACCCGAGTTCACAGATGTGGGAGAGCTGTAGAACCCTGAGTGTCAT
CGACTGGGCCTTCTTATGATTGTTGTTTTAAGATTAGCTGAAGATCTCTGAAACGCTGAA
TTTTCTGCACTGAGCGTTTTGACAGAATTCATTGAGAGAACAGAGAACATGACAAGTACT
TCTAGCTCAGCACTGCTCCAACTACTGAAGCTGATTTTCAAGGCTACTTAAAAAAATCTG
CAGCGTACATTAATGGATTTCTGTTGTGTTTAAATTCTCCACAGATTGTATTGTAAATAT
TTTATGAAGTAGAGCATATGTATATATTTATATATACGTGCACATACATTAGTAGCACTA
CCTTTGGAAGTCTCAGCTCTTGCTTTTCGGGACTGAAGCCAGTTTTGCATGATAAAAGTG
GCCTTGTTACGGGAGATAATTGTGTTCTGTTGGGACTTTAGACAAAACTCACCTGCAAAA
AACTGACAGGCATTAACTACTGGAACTTCCAAATAATGTGTTTGCTGATCGTTTTACTCT
TCGCATAAATATTTTAGGAAGTGTATGAGAATTTTGCCTTCAGGAACTTTTCTAACAGCC
AAAGACAGAACTTAACCTCTGCAAGCAAGATTCGTGGAAGATAGTCTCCACTTTTTAATG
CACTAAGCAATCGGTTGCTAGGAGCCCATCCTGGGTCAGAGGCCGATCCGCAGAACCAGA
ACGTTTTCCCCTCCTGGACTGTTAGTAACTTAGTCTCCCTCCTCCCCTAACCACCCCCGC
CCCCCCCCACCCCCCGCAGTAATAAAGGCCCCTGAACGTGTATGTTGGTCTCCCGGGAGC
TGCTTGCTGAAGATCCGCGCCCCTGTCGCCGTCTGGTAGGAGCTGTTTGCAGGGTCCTAA
CTCAATCGGCTTGTTGTGATGCGTATCCCCGTAGATGCCAGCACGAGCCGCCGCTTCACG
CCGCCTTCCACCGCGCTGAGCCCAGGCAAGATGAGCGAGGCGTTGCCGCTGGGCGCCCCG
GACGCCGGCGCTGCCCTGGCCGGCAAGCTGAGGAGCGGCGACCGCAGCATGGTGGAGGTG
CTGGCCGACCACCCGGGCGAGCTGGTGCGCACCGACAGCCCCAACTTCCTCTGCTCCGTG
CTGCCTACGCACTGGCGCTGCAACAAGACCCTGCCCATCGCTTTCAAG
Intró 1-2 6.129
gtactggcccggagagggtggtgggaggacaggcggaggccggcgaggccgggggagatc
............................................................
ccctaaaagtgtatgtataacatccctgatgtctgcatttgtcctttgactggtgtttag
Exó 2 157

GTGGTGGCCCTAGGGGATGTTCCAGATGGCACTCTGGTCACTGTGATGGCTGGCAATGAT
GAAAACTACTCGGCTGAGCTGAGAAATGCTACCGCAGCCATGAAGAACCAGGTTGCAAGA
TTTAATGACCTCAGGTTTGTCGGTCGAAGTGGAAGAG
Intró 2-3 20.978
gtacgttatctgtcaaaactatgcttgaaacacgtttcatggcaacaaacccacatttca
............................................................
caacagatatgttcaggccaccaacctcattctgttttgttctctatcgtgtccccacag
Exó 3 105
GGAAAAGCTTCACTCTGACCATCACTGTCTTCACAAACCCACCGCAAGTCGCCACCTACC
ACAGAGCCATCAAAATCACAGTGGATGGGCCCCGAGAACCTCGAA
Intró 3-4 24.872
gtaagtgcatccacttggggctggtacaccctccaggctggtacaccctccaggctggta
............................................................
gatctcttccctccctccttccctccccccatcccctcccctccctgctccccacaatag
Exó 4 192
GACATCGGCAGAAACTAGATGATCAGACCAAGCCCGGGAGCTTGTCCTTTTCCGAGCGGC
TCAGTGAACTGGAGCAGCTGCGGCGCACAGCCATGAGGGTCAGCCCACACCACCCAGCCC
CCACGCCCAACCCTCGTGCCTCCCTGAACCACTCCACTGCCTTTAACCCTCAGCCTCAGA
GTCAGATGCAGG
Intró 4-5 34.947
gtaagtaccagatggagcccactgcccgcctctcctgcacctgggccaccacccacaact
............................................................
aagacattttttaaatcccaccccactttacatataattgacctttctgattctcttcag
Exó 5 162
ATACAAGGCAGATCCAACCATCCCCACCGTGGTCCTACGATCAGTCCTACCAATACCTGG
GATCCATTGCCTCTCCTTCTGTGCACCCAGCAACGCCCATTTCACCTGGACGTGCCAGCG
GCATGACAACCCTCTCTGCAGAACTTTCCAGTCGACTCTCAA
Intró 5-6 6.690
gtaagccacttgaaaacacattctttgcagctgagctggggtggaaggtccaggagacta
............................................................
gagctgtggcctccgcaacctcctactcacttccgctccgttctcttgcccgccctgcag
Exó 6 4.803
CGGCACCCGACCTGACAGCGTTCAGCGACCCGCGCCAGTTCCCCGCGCTGCCCTCCATCT
CCGACCCCCGCATGCACTATCCAGGCGCCTTCACCTACTCCCCGACGCCGGTCACCTCGG
GCATCGGCATCGGCATGTCGGCCATGGGCTCGGCCACGCGCTACCACACCTACCTGCCGC
CGCCCTACCCCGGCTCGTCGCAAGCGCAGGGAGGCCCGTTCCAAGCCAGCTCGCCCTCCT
ACCACCTGTACTACGGCGCCTCGGCCGGCTCCTACCAGTTCTCCATGGTGGGCGGCGAGC
GCTCGCCGCCGCGCATCCTGCCGCCCTGCACCAACGCCTCCACCGGCTCCGCGCTGCTCA
ACCCCAGCCTCCCGAACCAGAGCGACGTGGTGGAGGCCGAGGGCAGCCACAGCAACTCCC
CCACCAACATGGCGCCCTCCGCGCGCCTGGAGGAGGCCGTGTGGAGGCCCTACTGAGGCG
CCAGGCCTGGCCCGGCTGGGCCCCGCGGGCCGCCGCCTTCGCCTCCGGGCGCGCGGGCCT
CCTGTTCGCGACAAGCCCGCCGGGATCCCGGGCCCTGGGCCCGGCCACCGTCCTGGGGCC
GAGGGCGCCCGACGGCCAGGATCTCGCTGTAGGTCAGGCCCGCGCAGCCTCCTGCGCCCA
GAAGCCCACGCCGCCGCCGTCTGCTGGCGCCCCGGCCCTCGCGGAGGTGTCCGAGGCGAC
GCACCTCGAGGGTGTCCGCCGGCCCCAGCACCCAGGGGACGCGCTGGAAAGCAAACAGGA
AGATTCCCGGAGGGAAACTGTGAATGCTTCTGATTTAGCAATGCTGTGAATAAAAAGAAA
GATTTTATACCCTTGACTTAACTTTTTAACCAAGTTGTTTATTCCAAAGAGTGTGGAATT
TTGGTTGGGGTGGGGGGAGAGGAGGGATGCAACTCGCCCTGTTTGGCATCTAATTCTTAT
TTTTAATTTTTCCGCACCTTATCAATTGCAAAATGCGTATTTGCATTTGGGTGGTTTTTA
TTTTTATATACGTTTATATAAATATATATAAATTGAGCTTGCTTCTTTCTTGCTTTGACC
ATGGAAAGAAATATGATTCCCTTTTCTTTAAGTTTTATTTAACTTTTCTTTTGGACTTTT
GGGTAGTTGTTTTTTTTTGTTTTGTTTTGTTTTTTTGAGAAACAGCTACAGCTTTGGGTC
ATTTTTAACTACTGTATTCCCACAAGGAATCCCCAGATATTTATGTATCTTGATGTTCAG
ACATTTATGTGTTGATAATTTTTTAATTATTTAAATGTACTTATATTAAGAAAAATATCA
AGTACTACATTTTCTTTTGTTCTTGATAGTAGCCAAAGTTAAATGTATCACATTGAAGAA
GGCTAGAAAAAAAGAATGAGTAATGTGATCGCTTGGTTATCCAGAAGTATTGTTTACATT
AAACTCCCTTTCATGTTAATCAAACAAGTGAGTAGCTCACGCAGCAACGTTTTTAATAGG
ATTTTTAGACACTGAGGGTCACTCCAAGGATCAGAAGTATGGAATTTTCTGCCAGGCTCA
ACAAGGGTCTCATATCTAACTTCCTCCTTAAAACAGAGAAGGTCAATCTAGTTCCAGAGG
GTTGAGGCAGGTGCCAATAATTACATCTTTGGAGAGGATTTGATTTCTGCCCAGGGATTT
GCTCACCCCAAGGTCATCTGATAATTTCACAGATGCTGTGTAACAGAACACAGCCAAAGT
AAACTGTGTAGGGGAGCCACATTTACATAGGAACCAAATCAATGAATTTAGGGGTTACGA
TTATAGCAATTTAAGGGCCCACCAGAAGCAGGCCTCGAGGAGTCAATTTGCCTCTGTGTG
CCTCAGTGGAGACAAGTGGGAAAACATGGTCCCACCTGTGCGAGACCCCCTGTCCTGTGC
TGCTCACTCAACAACATCTTTGTGTTGCTTTCACCAGGCTGAGACCCTACCCTATGGGGT
ATATGGGCTTTTACCTGTGCACCAGTGTGACAGGAAAGATTCATGTCACTACTGTCCGTG
GCTACAATTCAAAGGTATCCAATGTCGCTGTAAATTTTATGGCACTATTTTTATTGGAGG
ATTTGGTCAGAATGCAGTTGTTGTACAACTCATAAATACTAACTGCTGATTTTGACACAT
GTGTGCTCCAAATGATCTGGTGGTTATTTAACGTACCTCTTAAAATTCGTTGAAACGATT
TCAGGTCAACTCTGAAGAGTATTTGAAAGCAGGACTTCAGAACAGTGTTTGATTTTTATT
TTATAAATTTAAGCATTCAAATTAGGCAAATCTTTGGCTGCAGGCAGCAAAAACAGCTGG
ACTTATTTAAAACAACTTGTTTTTGAGTTTTCTTATATATATATTGATTATTTGTTTTAC
ACACATGCAGTAGCACTTTGGTAAGAGTTAAAGAGTAAAGCAGCTTATGTTGTCAGGTCG
TTCTTATCTAGAGAAGAGCTATAGCAGATCTCGGACAAACTCAGAATATATTCACTTTCA
TTTTTGACAGGATTCCCTCCACAACTCAGTTTCATATATTATTCCGTATTACATTTTTGC
AGCTAAATTACCATAAAATGTCAGCAAATGTAAAAATTTAATTTCTGAAAAGCACCATTA
GCCCATTTCCCCCAAATTAAACGTAAATGTTTTTTTTCAGCACATGTTACCATGTCTGAC
CTGCAAAAATGCTGGAGAAAAATGAAGGAAAAAATTATGTTTTTCAGTTTAATTCTGTTA
ACTGAAGATATTCCAACTCAAAACCAGCCTCATGCTCTGATTAGATAATCTTTTACATTG
AACCTTTACTCTCAAAGCCATGTGTGGAGGGGGCTTGTCACTATTGTAGGCTCACTGGAT
TGGTCATTTAGAGTTTCACAGACTCTTACCAGCATATATAGTATTTAATTGTTTCAAAAA
AAATCAAACTGTAGTTGTTTTGGCGATAGGTCTCACGCAACACATTTTTGTATGTGTGTG
TGTGTGCGTGTGTGTGTGTGTGTGTGAAAAATTGCATTCATTGACTTCAGGTAGATTAAG
GTATCTTTTTATTCATTGCCCTCAGGAAAGTTAAGGTATCAATGAGACCCTTAAGCCAAT
CATGTAATAACTGCATGTGTCTGGTCCAGGAGAAGTATTGAATAAGCCATTTCTACTGCT
TACTCATGTCCCTATTTATGATTTCAACATGGATACATATTTCAGTTCTTTCTTTTTCTC
ACTATCTGAAAATACATTTCCCTCCCTCTCTTCCCCCCAATATCTCCCTTTTTTTCTCTC
TTCCTCTATCTTCCAAACCCCACTTTCTCCCTCCTCCTTTTCCTGTGTTCTCTTAAGCAG
ATAGCACATACCCCCACCCAGTACCAAATTTCAGAACACAAGAAGGTCCAGTTCTTCCCC
CTTCACATAAAGGAACATGGTTTGTCAGCCTTTCTCCTGTTTATGGGTTTCTTCCAGCAG
AACAGAGACATTGCCAACCATATTGGATCTGCTTGCTGTCCAAACCAGCAAACTTTCCTG
GGCAAATCACAATCAGTGAGTAAATAGACAGCCTTTCTGCTGCCTTGGGTTTCTGTGCAG
ATAAACAGAAATGCTCTGATTAGAAAGGAAATGAATGGTTCCACTCAAATGTCCTGCAAT
TTAGGATTGCAGATTTCTGCCTTGAAATACCTGTTTCTTTGGGACATTCCGTCCTGATGA
TTTTTATTTTTGTTGGTTTTTATTTTTGGGGGGAATGACATGTTTGGGTCTTTTATACAT
GAAAATTTGTTTGACAATAATCTCACAAAACATATTTTACATCTGAACAAAATGCCTTTT
TGTTTACCGTAGCGTATACATTTGTTTTGGGATTTTTGTGTGTTTGTTGGGAATTTTGTT
TTTAGCCAGGTCAGTATTGATGAGGCTGATCATTTGGCTCTTTTTTTCCTTCCAGAAGAG
TTGCATCAACAAAGTTAATTGTATTTATGTATGTAAATAGATTTTAAGCTTCATTATAAA
ATATTGTTAATGCCTATAACTTTTTTTCAATTTTTTTGTGTGTGTTTCTAAGGACTTTTT
CTTAGGTTTGCTAAATACTGTAGGGAAAAAAATGCTTCTTTCTACTTTGTTTATTTTAGA
CTTTAAAATGAGCTACTTCTTATTCACTTTTGTAAACAGCTAATAGCATGGTTCCAATTT
TTTTTAAGTTCACTTTTTTTGTTCTAGGGGAAATGAATGTGCAAAAAAAGAAAAAGAACT
GTTGGTTATTTGTGTTATTCTGGATGTATAAAAATCAATGGAAAAAAATAAACTTTCAAA
TTGAAATGACGGTATAACACATCTACTGAAAAAGCAACGGGAAATGTGGTCCTATTTAAG
CCAGCCCCCACCTAGGGTCTATTTGTGTGGCAGTTATTGGGTTTGGTCACAAAACATCCT
GAAAATTCGTGCGTGGGCTTCTTTCTCCCTGGTACAAACGTATGGAATGCTTCTTAAAGG
GGAACTGTCAAGCTGGTGTCTTCAGCCAGATGACATGAGAGAATATCCCAGAACCCTCTC
TCCAAGGTGTTTCTAGATAGCACAGGAGAGCAGGCACTGCACTGTCCACAGTCCACGGTA
CACAGTCGGGTGGGCCGCCTCCCCTCTCCTGGGAGCATTCGTCGTGCCCAGCCTGAGCAG
GGCAGCTGGACTGCTGCTGTTCAGGAGCCACCAGAGCCTTCCTCTCTTTGTACCACAGTT
TCTTCTGTAAATCCAGTGTTACAATCAGTGTGAATGGCAAATAAACAGTTTGACAAGTAC
ATA
3' downstream
caccatatccaattggttttgtctttctctgagatggagggttgggaaactgagtaaggc