CLUSTAL W (1.82) multiple sequence alignment
D.mojavensis+1 VGSSPASLLQIVKFYYYKYGAEMMLLKSLRSSGSFRSVLLLRFAGSVRNAS--KFDYDLV 58
D.virililis+2 ------------------LPPKMLMFKALRNSRLPRSVLLLRFASSATTTSNCKYDYDLV 42
D.simulans-1 ------------------------------------------------------------
D.erecta-2 ------------------------------------------------------------
D.Pseudoobscura+1 --------------------NKMSLWKLLQVSSAIRS-----CARSASYLGKVKYDYDLV 35
D.ananaessis-1 -------------------GREML----LQTSGPSRTRIFSLLHQCRLASSKPRFDYDLV 37
D.yakuba+3 ------------------------------------------------------------
D.erecta+2 ------------------------------------------------------------
D.ananassae+2 ------------------------------------------------------------
D.melangaster -----------------------------------------------MAPVQGSYDYDLI 13
D.pseudoobscura-3 ------------------------------------------------------------
D.virilis+3 ------------------------------------------------------------
D.mojavensis-1 ------------------------------------------------------------
D.simulans+2 ------------------------------------------------------------
M.domestica ---------------------------------------------MSQAAGSHEYDYDLI 15
G.morsitans ------------------------------------------------------------
A.gambiae -------------------MATAVLARPARSLINVVQCVRLIRTQATVMFAKENYEYDLV 41
A.aegypti ------------------------------------------------------------
A.mellifera -------------------------------------------------------MYDLI 5
TR3 ------------------MAAMAVALRGLGGRFRWRTQAVAGGVRGAARGAAGQRDYDLL 42
D.mojavensis+1 VLGGGSGGLACAKEAVEYGARVLCLDYVKPTPAG-TKWGVGGTCVNVGCIPKKLMHQASL 117
D.virililis+2 VLGGGSGGLACAKEAVEYGAHVLCFDFVKPTPAG-TKWGVGGTCVNVGCIPKKLMHQASL 101
D.simulans-1 ------------------------------------------------------------
D.erecta-2 ------------------------------------------------------------
D.Pseudoobscura+1 VLGGGSAGLACAKEAVDNGARVLCFDYVKPTPVG-TKWGLGGTCVNVGCIPKKLMHQASL 94
D.ananaessis-1 VLGGGSAGLACAKEAVDCGARVLCFDYVKPTPVG-TKWGLGGTCVNVGCIPKKLMHQASL 96
D.yakuba+3 ------------------------------------------------------------
D.erecta+2 ------------------------------------------------------------
D.ananassae+2 ------------------------------------------------------------
D.melangaster VIGGGSAGLACAKEAVLNGARVACLDFVKPTPTLGTKWGVGGTCVNVGCIPKKLMHQASL 73
D.pseudoobscura-3 ------------------------------------------------------------
D.virilis+3 ------------------------------------------------------------
D.mojavensis-1 ------------------------------------------------------------
D.simulans+2 ------------------------------------------------------------
M.domestica VIGGGSGGLACAKEAVANGAKVACLDYVKP-TPLGTKWGIGGTCVNVGCIPKKLMHQASL 74
G.morsitans ------------------------------------------------------------
A.gambiae VIGGGSGGLACAKQAVQLGAKVAVLDFVKPSPRG-TKWGLGGTCVNVGCIPKKLMHQASL 100
A.aegypti ------------------------------------------NLRHVGCIPKKLMHQASL 18
A.mellifera VIGGGSGGLAAAKEAVNFGAKVAVLDFVTPSPRG-STWGLGGTCVNVGCIPKKLMHQAAL 64
TR3 VVGGGSGGLACAKEAAQLGRKVAVVDYVEPSPQG-TRWGLGGTCVNVGCIPKKLMHQAAL 101
D.mojavensis+1 LGEAVHEAVAYGWNVNDRDIKP-DWKKLVKVVQNHIKSVNWVTRVDLRDKKVEYVNSIGS 176
D.virililis+2 LGEAVHEAVAYGWNVNDQNIKP-DWKKLVKSVQDHIKSVNWVTRVDLRDKKVEYVNSIGR 160
D.simulans-1 ------------------------------------------------------------
D.erecta-2 ------------------------------------------------------------
D.Pseudoobscura+1 LGEAVHEAVAYGWNVNDQNIKP-DWQKLVKSVQNHIKSVNWVTRVDLRDKKVEYVNSMGT 153
D.ananaessis-1 LGEAVHEAVAYGWNVNDKNIRP-DWCKLVRSVQNHIKSVNWVTRVDLRDKKVEYVNSMGA 155
D.yakuba+3 ------------------------------------------------------------
D.erecta+2 ------------------------------------------------------------
D.ananassae+2 ------------------------------------------------------------
D.melangaster LGEAVHEAAAYGW-NVDEKIKP-DWHKLVQSVQNHIKSVNWVTRVDLRDKKVEYINGLGS 131
D.pseudoobscura-3 ------------------------------------------------------------
D.virilis+3 ------------------------------------------------------------
D.mojavensis-1 ------------------------------------------------------------
D.simulans+2 ------------------------------------------------------------
M.domestica LGESIHEATAYGWEIPNKEAIKPKWENLVQAVQNHIKSVNWVTRVDLRDKKVEYINGAGS 134
G.morsitans -------------------------------------------------------NITXG 5
A.gambiae LGEAIHDSQPYGWQLPDPAAIRHDWATLTESVQNHIKSVNWVTRVDLRDQKVEYVNGLGY 160
A.aegypti LGEAIHDAQPYGWKFAEPESVKHDWATLTESVQNHIKSVNWXTXVDLRDKKVEYVNGLGY 78
A.mellifera LGESIHDSVSYGWQLPDPKTIKNDWEALRTAVQNHVKSVNWVTRVELRTKKIEYFNALGY 124
TR3 LGGLIQDAPNYGWEVAQP--VPHDWRKMAEAVQNHVKSLNWGHRVQLQDRKVKYFNIKAS 159
D.mojavensis+1 FVNPHTIKYKTKQGELK-QLTAQYVVIAVGGRPRYP-PIKGAIELGITSDDIFSYEKEPG 234
D.virililis+2 FVDPHTIEYIQKQGERK-QLTAKYVVVAVGGRPRYP-SIPGATEFGITSDDIFSYEKEPG 218
D.simulans-1 ------------------------------------------------------------
D.erecta-2 ------------------------------------------------------------
D.Pseudoobscura+1 FVDPHTIEYSVKGGPKQ-QATAAYVVVAVGGRPRYP-PILGATEFGITSDDIFSYDREPG 211
D.ananaessis-1 FVDGHTIEYVPKSGQAKSRVTAKNVVVAVGGRPRYP-SIPGATEFGITSDDIFSYDREPG 214
D.yakuba+3 -----------------------------------------------------------P 1
D.erecta+2 -----------------------------------------------------------P 1
D.ananassae+2 ------------------------------------------------------------
D.melangaster FVDSHTLLAKLKSGERT--ITAQTFVIAVGGRPRYP-DIPGAVEYGITSDDLFSLDREPG 188
D.pseudoobscura-3 -------------------------------------------------------FLPSA 5
D.virilis+3 -----------------------------------------------VPSAFKSSYCASS 13
D.mojavensis-1 ------------------------------------------------------------
D.simulans+2 ------------------------------------------------------------
M.domestica FKDPHTVVAKMKNGSER-TLTGRNVVIAVGGRPRYP-DIPGAVEYGITSDDLFSLDKEPG 192
G.morsitans FXDSHTILVKMKNNTER-TVSARNIVIAVGGRPRYP-NIPG-AELGITSDDLFSLDKPPG 62
A.gambiae FKDDHTVVAVMKNQTER-ELRAKHVVIAVGGRPRYP-DIPGAAEYGITSDDIFSLPQAPG 218
A.aegypti FKDAHNVVAVMKNQTER-VLNTKNVVIAVGGRPRYP-NIPGALEHGITSDDIFSLXHEPG 136
A.mellifera FKDQHTILGKLKNGEEK-EFTAQNILIAVGGRPRYP-DIPGALEYGITSDDIFSLEKAPG 182
TR3 FVDEHTVCGVAK-GGKEILLSADHIIIATGGRPRYPTHIEGALEYGITSDDIFWLKESPG 218
D.mojavensis+1 RTLVVGAGYVGLECACFLKGLGYDPTVMVRSIVLRGFDRQMSEFLAAMMTERGIHFLNTT 294
D.virililis+2 RTLVVGAGYVGLECACFLKGLGYDPTVMVRSIVLRGFDRQMSEFLAAMMLERGIRFLNTT 278
D.simulans-1 ------------------------------------------------------------
D.erecta-2 ------------------------------------------------------------
D.Pseudoobscura+1 RTLVVGAGYVGLECACFLKGLGYDPTVMVRSIVLRGFDRQMSELLEAMMSERGVQFLHTT 271
D.ananaessis-1 RTLVVGAGYVGLECACFLKGLGYDPTVMVRSIVLRGFDRQMSELLAAMMSERGISFLETT 274
D.yakuba+3 IRFLLFHADIGLECAGFLKGLGYEPTVMVRSIVLRGFDQQMAELVAASMEERGIPFLRKS 61
D.erecta+2 IRFPLLHTDIGLECAGFLKGLGYEPTVMVRSIVLRGFDQQMAELVAASMEERGIPFLRKS 61
D.ananassae+2 -----SFADIGLECAGFLKGLGYEPTVMVRSIVLRGFDQQMAELVASSMEERGIPFLRKT 55
D.melangaster KTLVVGAGYIGLECAGFLKGLGYEPTVMVRSIVLRGFDQQMAELVAASMEERGIPFLRKT 248
D.pseudoobscura-3 LIHLCFHTDIGLECAGFLKGLGYEPTVMVRSIVLRGFDQQMAELVASSMDERGIPFLRKT 65
D.virilis+3 LTFVFRLADIGLECAGFLKGLGYEPTVMVRSIVLRGFDQQMANLVAASMEERGIPFLRKT 73
D.mojavensis-1 -----QLPDIGLECAGFLKGLGYEPTVMVRSIVLRGFDQQMANLVAAAMEERGIPFLRKT 55
D.simulans+2 ------------------------------------------------------------
M.domestica KTLVVGAGYIGLECAGFLKGLGYDATVMVRSIVLRGFDQQMANMVADSMVERGIPFLHKT 252
G.morsitans RTLIVGAGYIGLECAGFLRGLGYDATVMVRSIILRGFDQQMANMVADSMVERGVKFIHKT 122
A.gambiae RTLLVGAGYIGLECAGFLKGLGYDVSVMVRSILLRGFDQQMATMVGDSMVEKGIRFHHRS 278
A.aegypti KTLVVGAGYIGLECAGFLKGFGYDATVMVRSILLRGFDQQMATMVGDAMVEKGIKFLHKT 196
A.mellifera KTLIVGAGYIGLECAGFLNGLGYDATVMVRSIVLRGFDQQMASTVAQEMERRGVHFIYEA 242
TR3 KTLVVGASYVAWECAGFLTGIGLDTTIMMRTSPLRGFDQQMSSMVIEHMASHGTRFLRGC 278
D.mojavensis+1 IPMGVERTPEGKLLVQYRN---TTTQTDGSDVFDTVLWAIGRKGLIEDLNLGAAGVQTY- 350
D.virililis+2 IPLAVERRADGKLLVKYQN---TTTKTDGSDVFDTVLWAIGRKGLTEDLNLGAAGVQTY- 334
D.simulans-1 ------------------------------------------------------------
D.erecta-2 ------------------------------------------------------GLK--- 3
D.Pseudoobscura+1 IPSSVERQGDGRLLVKYRN---TTTEKEDSDVFDTVLWAIGRKGLIEDLNLPAAGVETK- 327
D.ananaessis-1 IPSSVERQSDGRLLVRFRN---TTTQTDGSDVFDTVLWAIGRRGLIEDLNLEAAGVKTQ- 330
D.yakuba+3 VPLSVEKQDDGKLLVKYKN---VETGEEAEDVFDTVLWAIGRKGLVDDLNLPNAGVTVQ- 117
D.erecta+2 VPLSVQKQDDGKLLVKYKN---VETDEEAEDVFDTVLWAIGRKGLVDDLNLPNAGVTVQ- 117
D.ananassae+2 VPLSVEKQEDGKLLVKFKN---VETGEEAEDTFDTVLWAIGRKGLVDDLNLPNAGVNTQ- 111
D.melangaster VPLSVEKQDDGKLLVKYKN---VETGEEAEDVYDTVLWAIGRKGLVDDLNLPNAGVTVQ- 304
D.pseudoobscura-3 VPLSVTKQDNGKLLVKYKN---TETGEEGEDTYDTVLWAVGRKGLVEDLNLSNAGVTTF- 121
D.virilis+3 VPLSVEKQSDGRLLVKYEN---TETGEIDSDVFDTVLWAIGRKGLVEDLNLHNAGVLTH- 129
D.mojavensis-1 VPLSVEKQSDGRLLVKYEN---TETGEVDSDVFDTVLWAIGRKGLVDDLNLDNAGVLTH- 111
D.simulans+2 ------------------------------------------------------------
M.domestica IPKSVEKTQDGRLLVKYVN---TETQEEGSDVYDTVLWAIGRKGLVDDLNLGAAGIEVK- 308
G.morsitans IPKSVEKTXHNTYLVKYIN---IETKEEGSDEYDTVMWAIGRKGLLEDLNLTSIGIELK- 178
A.gambiae RPLAVEKQPDGRLLVRYETVDEAGTATNGEDVFDTVLFAIGRQAETGTLKLANAGVVTAE 338
A.aegypti QPQSVEKQADGRLLVKYR----SDDGTEGSDVYDTVLFAIGRTACTDDLKLDQAGVVTAE 252
A.mellifera KPSKIEKQADGRLLVHWVD----KDRQTHQDTFDTVLFAIGRKPLTEELKPENIGLKLVP 298
TR3 APSRVRRLPDGQLQVTWED---STTGKEDTGTFDTVLWAIGRVPDTRSLNLEKAGVDTSP 335
D.mojavensis+1 ---NDKVIVDHTEA-TSVPHIFAVGDIIYGRPELTPVAILSGRLLARRLFAGSTQLMDYT 406
D.virililis+2 ---NDKIIVDHTEA-TNVPHIFAVGDIIYGRPELTPVAILSGRLLARRLFAGSTQLMDYT 390
D.simulans-1 ------------------------------------------------------------
D.erecta-2 ---DDKIVVDAAEA-TSVPHIFAVGDIIFGRPELTPVAILAGRLLARRLFAGATQLMDYD 59
D.Pseudoobscura+1 ---NDKIVVDSKEA-TNVPHIFAVGDIIHGRPELSPVAILSGRLLARRLFAGSKQLMDYA 383
D.ananaessis-1 ---NDKIVVDRSEA-TNVPHIFAVGDIVYGRPELTPVAILAGRLLARRLFAGSTQLMDYA 386
D.yakuba+3 ---KDKIPVDSQEA-TNVANIYAVGDIIYGKPELTPVAVLAGRLLARRLYGGATQRMDYK 173
D.erecta+2 ---KDKIPVDSQEA-TNVANIYAVGDIIYGKPELTPVAVLAGRLLARRLYGGATQRMDYN 173
D.ananassae+2 ---KDKIPVDSQEA-TNVANIYAVGDIIYGKPELTPVAILAGRLLARRLYGGATQRMDYA 167
D.melangaster ---KDKIPVDSQEA-TNVANIYAVGDIIYGKPELTPVAVLAGRLLARRLYGGSTQRMDYK 360
D.pseudoobscura-3 ---KDKIQVDTKEA-TNVANIFAVGDIIYGKPELTPVAVLAGRLLARRLYGGSNQRMDYS 177
D.virilis+3 ---KDKIQVDCEET-TNVPHIYAVGDIIYGKPELTPVAVLAGRLLARRLYADSDLRMDYA 185
D.mojavensis-1 ---KDKIQVDCEET-TNVPHIYAVGDIIYGKPELTPVAVLAGRLLARRLYADSELRMDYV 167
D.simulans+2 -------TARAQEG-TTVH----APDSLRG--------------LGRGAFS--------- 25
M.domestica ---ADKIAVNEAEQ-TNVPHIFAVGDIIHGRPELTPVAIHAGRLLARRLFGGSKQIMDYT 364
G.morsitans ---NDKILVNDAEQ-TNVSNVYAVGDITYGRPELTPVAIXAGRLLARRLFGNSTQLMNYC 234
A.gambiae GGKSDKLEVDETDHRTNVPHIYAVGDVLYRKPELTPVAIHAGRIIARRLFGGSEERMDYA 398
A.aegypti GGKSDKLDVDSFET-TNVPNIFAVGDVLYKRPELTPVAIHAGRLLARRLFNNQTDIMDYA 311
A.mellifera ----ETAKIDAIDEQTNVPNVYAVGDVLHKKPELTPVAIHAGRLLARRLFGNSTEQMDYV 354
TR3 --DTQKILVDSREA-TSVPHIYAIGDVVEGRPELTPTAIMAGRLLVQRLFGGSSDLMDYD 392
D.mojavensis+1 DVATTVFTPLEYSCVGMSEEMAIERLGADNIEVFHGYYKPTEFFIPQKSFRHCYLKAVAE 466
D.virililis+2 DVATTVFTPLEYSCVGMSEEMAIEKMGAENIEVFHAYYKPTEFFIPQKSVRHCYLKAVAE 450
D.simulans-1 ------------------EETAIELRGADNIEVFHGYYKPTEFFIPQKSVRHCYLKAVAE 42
D.erecta-2 DVATTVFTPLEYSCVGMSEETAIALRGADNIEVFHGYYKPTEFFIPQKSVRHCYLKAVAE 119
D.Pseudoobscura+1 DVATTVFTPLEYSCVGMSEEMAIQTHGPDNIEVFHGYYKPTEFFIPRKSVRHCYLKAVAE 443
D.ananaessis-1 DVATTVFTPLEYACVGMSEETAIEKHGADNIEVFHGYYKPTEFFIPQKSVRFCYLKAVAE 446
D.yakuba+3 DVATTVFTPLEYACVGLSEEDAVKEYGADEIEVFHGYYKPTEFFIPQKSVRYCYLKAVAE 233
D.erecta+2 DVATTVFTPLEYACVGLSEEEAVKQYGADEIEVFHGYYKPTEFFIPQKSVRYCYLKAVAE 233
D.ananassae+2 DVATTVFTPLEYACVGLSEEDAVKQYGADEVEVFHGYYKPTEFFIPQKSVRYCYLKAVAE 227
D.melangaster DVATTVFTPLEYACVGLSEEDAVKQFGADEIEVFHGYYKPTEFFIPQKSVRYCYLKAVAE 420
D.pseudoobscura-3 DVATTVFTPLEYACVGLSEEDAVKQHGADGVEVFHGYYKPTEFFIPQKSVRYCYLKAVAE 237
D.virilis+3 DVATTVFTPLEYACVGLSEEDAVKTYGAEEIEVFHGYYKPTEFFIPQKSVRYCYVKAVAQ 245
D.mojavensis-1 DVATTVFTPLEYACVGLSEEDAIKLYGAEEIEVFHGYYKPTEFFIPQKSVRYCYVKAVAQ 227
D.simulans+2 -----------------SRSDEIKCS---------RYYKPTEFFIPQKSVRYCYLKAVAE 59
M.domestica DVATTVFSPLEYACVGMAEEDAIQKFGEDNIEVFHGFYKPTEFFIPQKSVRYCYVKAVAE 424
G.morsitans NVATTVFSPLEYACVGMSEEDAAQEYGEDNIEVFHGFYKPTEFFIPQKSVRYCYVKAVAE 294
A.gambiae DVATTVFTPLEYGCVGLSEEAAEAAHGKDGIEVYHAYYKPTEFFVPQRSVRYCYLKAVAL 458
A.aegypti DVATTVFSPLEYGCVGMSEENAEAKFGKDKVEVYHAYYKPTEFFVPQRSVRYCYLKAVAL 371
A.mellifera NVATTVFSPLEYGCVGLSEEAAIAIHGNDKIEIYHAYYKPTEFFIPQKDVSNCYLKVIAF 414
TR3 NVPTTVFTPLEYGCVGLSEEEAVARHGQEHVEVYHAHYKPLEFTVAGRDASQCYVKMVCL 452
.. .*** ** :. :. **:* :.
D.mojavensis+1 VSGDQKILGLHYIGPVAGEVIQGFAAALKSGLTVKTLLNTVGIHPTTAEEFTRLSITKRS 526
D.virililis+2 VSGDQKILGLHYIGPVAGEVIQGFAAALKSGLTVKTLLNTVGIHPTTAEEFTRLSITKRS 510
D.simulans-1 VSGDQKILGLHYIGPVAGEVIQGFFAALKSGLTVKTVLNTVGIHPTTAEEFTRLSITKRS 102
D.erecta-2 VSGDQKILGLHYIGPVAGEVIQGFAAALKSGLTVKTLLNTVGIHPTTAEEFTRLSITKRS 179
D.Pseudoobscura+1 ITGDQKILGLHYIGPVAGEVIQGFAAALKSGLTVKTLLNTVGIHPTTAEEFTRLSITKRS 503
D.ananaessis-1 IAGDQKILGLHYMGPVAGEVIQGFAAALKSGLTVKTLLNTVGIHPTTAEEFTRLSITKRS 506
D.yakuba+3 RHGDQRVYGLHYIGPVAGEVIQGFAAALKSGLTINTLINTVGIHPTTAEEFTRLAITKRS 293
D.erecta+2 RHGDQRVYGLHYIGPVAGEVIQGFAAALKSGLTINTLINTVGIHPTTAEEFTRLAITKRS 293
D.ananassae+2 RHGDQRVYGLHYIGPVAGEVIQGFAAALKSGLTINTLINTVGIHPTTAEEFTRLNITKRS 287
D.melangaster RHGDQRVYGLHYIGPVAGEVIQGFAAALKSGLTINTLINTVGIHPTTAEEFTRLAITKRS 480
D.pseudoobscura-3 RTGDQRVYGLHYLGPVAGEVIQGFAAALKSGLTINTLINTVGIHPTTAEEFTRLSITKRS 297
D.virilis+3 RSGEQRVYGLHYLGPVAGEVIQGFAAALKSGLTIPTLMNTVGIHPTTAEEFTRLSITKRS 305
D.mojavensis-1 RNGEQRVYGLHYLGPVAGEVIQGFAAALKSGLTIPTLMNTVGIHPTTAEEFTRLSITKRS 287
D.simulans+2 RHGDQRVYGLHYIGPVAGEVIQGFAAALKSGLTINTLINTVGIHPTTAEEFTRLAITKRS 119
M.domestica RSGDQKVLGLHYLGPVAGEVIQGFAAAVKSGLTMKILLNTVGIHPTTAEEFTRLAITKRS 484
G.morsitans RSGDQRVLGLHYLGPVAGEIIQGFAAAVKCGLTMKILMNTVGIHPTTAEEFTXLNITKRS 354
A.gambiae REGNQRVLGLHFLGPAAGEVIQGFAAALKCGLTMQVLRNTVGIHPTVAEEFTRLAITKRS 518
A.aegypti LEGDQKVLGLHFLGPVAGEVIQGFAAALKSGLTMKILKNTVGIHPTVAEEFTRLLITKSS 431
A.mellifera RNGDQRVLGMHFIGPNAGEVIQGFAAAIKCNLTFPKLKDTVGIHPTVAEEFTRISVTKRS 474
TR3 REPPQLVLGLHFLGPNAGEVTQGFALGIKCGASYAQVMRTVGIHPTCSEEVVKLRISKRS 512
* : *:*::** ***: *** .:*.. : : ******* :**.. : ::* *
D.mojavensis+1 GVDPTPASCCS 537
D.virililis+2 GRDPTPASCCS 521
D.simulans-1 GRDPTPASCCS 113
D.erecta-2 GRDPTPASCCS 190
D.Pseudoobscura+1 GRDPTPASCCS 514
D.ananaessis-1 GRDPTPASCCS 517
D.yakuba+3 GLDPTPASCCS 304
D.erecta+2 GLDPTPASCCS 304
D.ananassae+2 GLDPTPATCCS 298
D.melangaster GLDPTPASCCS 491
D.pseudoobscura-3 GLDPTPASCCS 308
D.virilis+3 GLDPTPASCCS 316
D.mojavensis-1 GLDPTPASCCS 298
D.simulans+2 GLDPTPASCCS 130
M.domestica GLDPTPASCCS 495
G.morsitans GADPTPASCCS 365
A.gambiae GLDPTPATCCS 529
A.aegypti GLDPTPATCCS 442
A.mellifera GLDPKPQSCCS 485
TR3 GLDPTVTGCUG 523
* **. * .