ORGANISM: Human herpesvirus 8
LINEAGE: Viruses; dsDNA viruses, no RNA stage; Herpesviridae; Gammaherpesvirinae; Rhadinovirus
PRODUCT: dUTPase homolog; EBV BLLF3 homolog
GENE: ORF 54
FUNCTION: encodes a functional dUTPase which specifically hydrolyses dUTP to dUMP and is expressed early in the lytic replication cycle
CONSERVED DOMAIN: dUTPase; dUTPase hydrolyses dUTP to dUMP and pyrophosphate. Deoxycytidine deaminase
*****
ORGANISM: Macaca mulatta rhadinovirus
LINEAGE: Viruses; dsDNA viruses, no RNA stage; Herpesviridae; Gammaherpesvirinae; Rhadinovirus
PRODUCT: dUTPase
GENE: ORF 54
SCORE: 223 (identity 41%)
FUNCTION: encodes a functional dUTPase which specifically hydrolyses dUTP to dUMP and is expressed early in the lytic replication cycle
*****
ORGANISM: Equine herpesvirus 2
LINEAGE: Viruses; dsDNA viruses, no RNA stage; Herpesviridae; Gammaherpesvirinae
PRODUCT:deoxyuridine triphosphatase 54
GENE: ORF 54
SCORE: 186 (identity 37%)
FUNCTION: encodes a functional dUTPase which specifically hydrolyses dUTP to dUMP and is expressed early in the lytic replication cycle
PAPER: The DNA sequence of equine herpesvirus 2.Telford EA, Watson MS, Aird HC, Perry J, Davison AJ.J Mol Biol. 1995 Jun 9;249(3):520-8.
*****
ORGANISM: Saimiriine herpesvirus 2
LINEAGE: Viruses; dsDNA viruses, no RNA stage; Herpesviridae; Gammaherpesvirinae; Rhadinovirus
PRODUCT:dUTPase
GENE: ORF 54
SCORE: 177 (identity 34%)
FUNCTION: encodes a functional dUTPase which specifically hydrolyses dUTP to dUMP and is expressed early in the lytic replication cycle
PAPER:Primary structure of the herpesvirus saimiri genome. Albrecht JC, Nicholas J, Biller D, Cameron KR, Biesinger B, Newman C, Wittmann S, Craxton MA, Coleman H, Fleckenstein B, et al.J Virol. 1992 Aug;66(8):5047-58.
*****
ORGANISM: Ateline herpesvirus 3
LINEAGE: Viruses; dsDNA viruses, no RNA stage; Herpesviridae; Gammaherpesvirinae; Rhadinovirus
PRODUCT:hypotetical protein
GENE: ORF 54
SCORE: 176 (identity 33%)
FUNCTION: desconeguda
*****
ORGANISM: Alcelaphine herpesvirus
LINEAGE: Viruses; dsDNA viruses, no RNA stage; Herpesviridae; Gammaherpesvirinae; Rhadinovirus
PRODUCT:dUTPase
GENE: ORF 54
SCORE: 134 (identity 30%)
FUNCTION: encodes a functional dUTPase which specifically hydrolyses dUTP to dUMP and is expressed early in the lytic replication cycle
*****
ORGANISM: Callitrichine herpesvirus 3
LINEAGE: Viruses; dsDNA viruses, no RNA stage; Herpesviridae; Gammaherpesvirinae; Lymphocryptovirus
PRODUCT: ORF 48
SCORE: 131 (identity 33%)
FUNCTION: encodes a functional dUTPase which specifically hydrolyses dUTP to dUMP and is expressed early in the lytic replication cycle
PAPER: Complete genomic sequence of an Epstein-Barr virus-related herpesvirus naturally infecting a new world primate: a defining point in the evolution of oncogenic lymphocryptoviruses.Rivailler P, Cho YG, Wang F.J Virol. 2002 Dec;76(23):12055-68.
*****
ORGANISM: Bovine herpesvirus 4
LINEAGE: Viruses; dsDNA viruses, no RNA stage; Herpesviridae; Gammaherpesvirinae
PRODUCT: dUTPase
GENE: ORF 54
SCORE: 125 (identity 34%)
FUNCTION: encodes a functional dUTPase which specifically hydrolyses dUTP to dUMP and is expressed early in the lytic replication cycle
PAPER: Genome sequence of bovine herpesvirus 4, a bovine Rhadinovirus, and identification of an origin of DNA replication.Zimmermann W, Broll H, Ehlers B, Buhk HJ, Rosenthal A, Goltz M.J Virol. 2001 Feb;75(3):1186-94.
*****
ORGANISM: Cercopithicine herpesvirus 15
LINEAGE: Viruses; dsDNA viruses, no RNA stage; Herpesviridae; Gammaherpesvirinae; Lymphocryptovirus; human herpesvirus 4
PRODUCT: dUTPase
NOTE: similar to Epstein-Barr virus BLLF3
SCORE: 122 (identity 32%)
FUNCTION: encodes a functional dUTPase which specifically hydrolyses dUTP to dUMP and is expressed early in the lytic replication cycle
*****
ORGANISM: Human herpesvirus 4 (Epstein-Barr)
LINEAGE: Viruses; dsDNA viruses, no RNA stage; Herpesviridae; Gammaherpesvirinae; Lymphocryptovirus
PRODUCT: dUTPase
GENE: BLLF3
SCORE: 120 (identity 32%)
FUNCTION: encodes a functional dUTPase which specifically hydrolyses dUTP to dUMP and is expressed early in the lytic replication cycle
PAPER: DNA sequence and expression of the B95-8 Epstein-Barr virus genome.Baer R, Bankier AT, Biggin MD, Deininger PL, Farrell PJ, Gibson TJ, Hatfull G, Hudson GS, Satchwell SC, Seguin C, et al. Nature. 1984 Jul 19-25;310(5974):207-11.
*****
ORGANISM: Murid herpesvirus 4
LINEAGE: Viruses; dsDNA viruses, no RNA stage; Herpesviridae; Gammaherpesvirinae
PRODUCT: dUTPase
GENE: ORF 54
SCORE: 103 (identity 32%)
FUNCTION: encodes a functional dUTPase which specifically hydrolyses dUTP to dUMP and is expressed early in the lytic replication cycle
PAPER: Complete sequence and genomic analysis of murine gammaherpesvirus 68.Virgin HW 4th, Latreille P, Wamsley P, Hallsworth K, Weck KE, Dal Canto AJ, Speck SH.J Virol. 1997 Aug;71(8):5894-904.