ClustalW. Múltiple séquense aligment

AFAMIN

: conserved cysteine

X : conserved pattern

X : domain

 

 

AFAM_RAT        MRHLKLTGFIFFLLSLTESLALPTKPQDVDHFNATQKFINENVAYLTIIASAQYVQEASF 60

AFAM_MOUSE      MRHLKLTGFIFFLLPLTESLALPTKPQDVDHFNATQKFIDENTAYLAIIAFSQYVQEASF 60

AFAM_HUMAN      MKLLKLTGFIFFLFFLTESLTLPTQPRDIENFNSTQKFIEDNIEYITIIAFAQYVQEATF 60

                *: **********: *****: ***:*:*:::**:*****::*  *::*** :******:*

 

AFAM_RAT        EEVEMLVKVMLDYKDRCLADSTLPECSKIANDAIQDMLCDMKGLPQKHNFSHCCRQAGFQ 120

AFAM_MOUSE      DEVETLVKVMLDYRDRCWADNTLPECSKTANDAIQDMLCDMEGLPQKHNFSHCCGKAGFP 120

AFAM_HUMAN      EEMEKLVKDMVEYKDRCMADKTLPECSKLPNNVLQEKICAMEGLPQKHNFSHCCSKVDAQ 120

                :*:* *** *::*:*** **.******* .*:.:*: :* *:************ :.. 

 

AFAM_RAT        RRLCFFYNKKANVGFLPPFPTLDPEEKCQAYKNNSESFLNLYMYEVARRNPFAFAPVLLN 180

AFAM_MOUSE      RRLCFFYNKKANVGFLPPFPTLDPEEKCQAYKNKSESFLHLYMYEVARRNPFVFAPVLLA 180

AFAM_HUMAN      RRLCFFYNKKSDVGFLPPFPTLDPEEKCQAYESNRESLLNHFLYEVARRNPFVFAPTLLT 180

                **********::*******************:.: **:*: ::*********.***.**

 

AFAM_RAT        VAARFEEAATTCCEQQQKATYFQDKAAPITQYLKALSSYQRNVCGALLKFGPKTLNSINI 240

AFAM_MOUSE      VAAWFEEAATTCCEQQQKATCFQAKAAPITQYLKASSSYQRNVCGALIKFGPKVLNSINV 240

AFAM_HUMAN      VAVHFEEVAKSCCEEQNKVNCLQTRAIPVTQYLKAFSSYQKHVCGALLKFGTKVVHFIYI 240

                **. ***.*.:***:*:*.. :* :* *:****** ****::*****:***.*.:: * :

 

AFAM_RAT        AVFSKKFPKIGFEDLTSLLEDVSSMYDGCCEGDVVQCIRSQSQVMHHICSKQDSISSKIK 300

AFAM_MOUSE      AVFSKKFPKIGFKDLTTLLEDVSSMYEGCCEGDVVHCIRSQSQVENHICSKQDSISSKIK 300

AFAM_HUMAN      AILSQKFPKIEFKELISLVEDVSSNYDGCCEGDVVQCIRDTSKVMNHICSKQDSISSKIK 300

                *::*:***** *::* :*:***** *:********:***. *:* :**************

 

AFAM_RAT        ACCEKKLPERADCIINANKDDRPEDLSLRTPKFTDSENVCQERDSEQDKFFAEFLYDYSR 360

AFAM_MOUSE      VCCEKKTLEREACIINANKDDRPEGLSLREAKFTESENVCQERDSDPDKFFAEFIYEYSR 360

AFAM_HUMAN      ECCEKKIPERGQCIINSNKDDRPKDLSLREGKFTDSENVCQERDADPDTFFAKFTFEYSR 360

                 *****  **  ****:******:.****  ***:*********:: *.***:* ::***

 

AFAM_RAT        RHTELSTPELLRITKVYKDLLEDCCNRKNPLSCYRHAEDKFNETTERSLAMVQQECKQFQ 420

AFAM_MOUSE      RHPDLSTPRLLRITKVYMDFLEDCCSRENPAGCYRHVEDKFNETTQRSLAMVQQECNQFQ 420

AFAM_HUMAN      RHPDLSIPELLRIVQIYKDLLRNCCNTENPPGCYRYAEDKFNETTEKSLKMVQQECKHFQ 420

                **.:** *.****.::* *:*.:**. :** .***:.********::** ******::**

 

AFAM_RAT        ELGKDALQRHFLVKFTKAAPQLPMEELVSLSKEMVAALATCCTLSDEFACVDNLADLVLG 480

AFAM_MOUSE      ELGKDTLQRHFLVKFTKAAPQLPMEELVSLSKEMVAALTTCCTLSDEFACVDNLADLVLG 480

AFAM_HUMAN      NLGKDGLKYHYLIRLTKIAPQLSTEELVSLGEKMVTAFTTCCTLSEEFACVDNLADLVFG 480

                :**** *: *:*:::** ****. ******.::**:*::******:************:*

 

AFAM_RAT        ELCGMNKNRTINPTVDHCCRADFAFRRPCFEHLKADTTYALPSVSALVSALRADWCQPLK 540

AFAM_MOUSE      ELCGVNTNRTINPAVDHCCKTDFAFRRHCFEHLKADTTYALPSVSALVSALHTDWCQPRK 540

AFAM_HUMAN      ELCGVNENRTINPAVDHCCKTNFAFRRPCFESLKADKTYVPPPFSQDLFTFHADMCQSQN 540

                ****:* ******:*****:::***** *** ****.**. *..*  : ::::* **. :

 

AFAM_RAT        EDLQNKRHRFLVNLVKWMPEITDEERLCLFTKFTAAGEECGNIQKPEACFSPESSKTGDV 600

AFAM_MOUSE      EDLQNKKHRFLVNLVKWMPGITDEEWLCLFTKFTAAREECSEVQEPESCFSPESSKTGDE 600

AFAM_HUMAN      EELQRKTDRFLVNLVKLKHELTDEELQSLFTNFANVVDKCCKAESPEVCFNEESPKIGN- 599

                *:**.* .********    :****  .***:*: . ::* : :.** **. **.* *:

 

AFAM_RAT        SQDAEKQR--- 608

AFAM_MOUSE      SQATENKITDQ 611

AFAM_HUMAN      -----------